| Set | Manufacturer | Year | Category | |
| Adrenaline | Fleer | 2000 | Novelty | |
| Angel (season 1) | Inkworks | 2000 | TV | |
| Angel (season 2) | Inkworks | 2000 | TV | |
| Backstreet Boys On Tour | Winterland / Panini | 2000 | Music | |
| Battlefield Earth | Upper Deck | 2000 | Movie | § |
| Beatles Yellow Submarine Jumbo, The | DuoCards | 2000 | TV | |
| Boris Karloff Return of the Monster Promo Set | Good Stuff Cards | 2000 | Movie | |
| Buffy the Vampire Slayer | Buffy Fan Club / Inkworks | 2000 | Buffy | |
| Buffy The Vampire Slayer (series 4) | Inkworks | 2000 | Buffy | |
| Buffy the Vampire Slayer Reflections: The High School Years | Inkworks | 2000 | Buffy | |
| CardCaptors | Upper Deck | 2000 | Anime / Manga | |
| CATS | Universal Studios | 2000 | Movie | |
| Celebrate America: 50 States (series 1) | Doral | 2000 | History & Nostalgia | |
| Celebrate America: Road Trip | Doral | 2000 | History & Nostalgia | |
| Charmed | Inkworks | 2000 | TV | |
| Chicken Run Platinum Collection | Futera | 2000 | Movie | |
| Chicken Run Sticker Collection | Futera | 2000 | Movie | |
| Christina Aguillera | Upper Deck | 2000 | Music | |
| Civil War Card Set, The (series 1) | TIMEtraders | 2000 | History & Nostalgia | |
| Classic Book Cards 2 | Between the Covers & Biblioctopus | 2000 | Product & Merchandising | |
| Coca-Cola Christmas, Holiday Collector Cards | Comic Images | 2000 | Product & Merchandising | |
| Coin Trading Cards 2000 | Numismaticards | 2000 | Product & Merchandising | |
| Crimson Commemorative | Dynamic Forces | 2000 | Other Action Comics | |
| DarkChylde 5th Anniversary | Dynamic Forces | 2000 | Other Action Comics | |
| Digimon 2 | Upper Deck | 2000 | Anime / Manga | |
| Digimon Animation Edition | Upper Deck | 2000 | Anime / Manga | |
| Digimon Movie Promo Set | Bandai | 2000 | Anime / Manga | |
| Digimon Photocards (Brazil) | Panini | 2000 | Anime / Manga | |
| Disney World Merchantainment | Disney | 2000 | Disney & Animated Movies | |
| Disneyana Convention 2000: It's a Small World | Disney | 2000 | Disney & Animated Movies | |
| Doctor Who Definitive 1 | Strictly Ink | 2000 | TV | |
| Esquire Playing Cards | Esquire U.K. | 2000 | Product & Merchandising | |
| Farscape (season 1) | Rittenhouse Archives | 2000 | TV | |
| Farscape in Motion Lenticular 9-Card Preview | Rittenhouse Archives | 2000 | TV | |
| Farscape, The Ships of | Rittenhouse Archives | 2000 | TV | |
| Final Fantasy Art Museum (1st edition) | Square | 2000 | Anime / Manga | |